What is Diagnostic Pathology?

The cause of disease is determined by morphologic and/or clinical pathology findings, as well as history, clinical signs, and ancillary test results. It is essential in all areas of pathology, both naturally occurring and experimentally induced disease.

It is critical in experimental studies to distinguish between the effects of spontaneous disease and those caused by the experimental agent/test article. Diagnostic pathology is required to investigate unexpected disease or death in laboratory animal colonies or before the study is terminated.

Pathology will remain important in the veterinary diagnostic laboratory for the diagnosis and prevention of spontaneous, chemically-induced disease. The value of naturally occurring chemically-induced diseases as models should not be underestimated, as these cases frequently add critical information to our understanding of the mechanisms of toxicity of these and similar chemical groups.



Introduction

Historically, the histologic appearance of diseased and normal tissues when stained with conventional stains, usually hematoxylin and eosin, has been the touchstone of diagnostic pathology. These tissues' microscopic appearance reflects their cellular structure, which is caused by the differential expression of approximately 20,000 protein-coding genes in the human genome. In the 1960s, the development of immunohistochemical techniques enabled the histologic detection of specific proteins, revolutionising both diagnostic pathology and the scientific study of disease.

Changes in DNA, transcription, and mRNA splicing, as well as changes in other aspects of the complex regulation of RNA metabolism and translation, all contribute to the differential expression of specific proteins. With the sequencing of the human genome and recent advances in both PCR-based and array-based technologies that enable easy quantitation of specific RNA levels, simultaneous detection of tens or hundreds of thousands of different genetic transcripts, and DNA-based technologies for studying genetic changes and chromosomal organisation, we are now on the verge of another, similar revolution.

Goals and scope:

Diagnostic Pathology is an open access, peer-reviewed online journal that focuses on research in surgical and clinical pathology, immunology, and biology, with a particular emphasis on cutting-edge diagnostic pathology and tissue-based therapy.

The covers all aspects of surgical pathology, such as classic diagnostic pathology, prognosis-related diagnosis (tumour stages, prognosis markers like MIB-percentage, hormone receptors, and so on), and therapy-related findings. The journal also focuses on pathology's technological aspects, such as molecular biology techniques, morphometry (stereology, DNA analysis, syntactic structure analysis), communication (telecommunication, virtual microscopy, virtual pathology institutions, and so on), and electronic education and quality assurance (for example interactive publication, on-line references with automated updating, etc.).

Definition:

Diagnostic pathology is a medical specialty that focuses on disease diagnosis through the morphological examination of cells, tissues, and organs. The study of diseases is known as pathology.

Diagnostic Pathology has emerged as a premier journal that aims to publish cutting-edge diagnostic pathology articles with an emphasis on novel morphological and molecular findings that impact the diagnosis of neoplastic and non-neoplastic diseases. The editorial board and our team's goal is to highlight the intersections of diagnostic pathology and new tools and technologies that are exciting, challenging, and making an impact on pathology practise.

We will continue to provide updates in the field of diagnostic pathology through novel and interesting case reports, research and original articles, and a series of key review articles written by experts in the field that will emphasise disease-specific new developments and highlight contemporary and novel technologies that are changing diagnostic pathology practice.

This is an exciting time in pathology because we are confronted with a new frontier of science and technology that continues to evolve and accelerate the discipline of diagnostic pathology, and we want to take our readers along for the ride. We want to work with our reviewers and readers to make Diagnostic Pathology a premier and trusted source of new and exciting diagnostic pathology developments."

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